Sverre Holm Selected Research

Carotid Artery Diseases

12/2020	N6-methyladenosine in RNA of atherosclerotic plaques: An epitranscriptomic signature of human carotid atherosclerosis.
10/2020	Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis.
1/2020	Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages.
7/2017	Increased expression of TFPI in human carotid stenosis.
1/2017	Increased levels of legumain in plasma and plaques from patients with carotid atherosclerosis.
1/2017	Leukocyte Overexpression of Intracellular NAMPT Attenuates Atherosclerosis by Regulating PPARγ-Dependent Monocyte Differentiation and Function.
1/2017	Interleukin 27 is increased in carotid atherosclerosis and promotes NLRP3 inflammasome activation.
4/2016	The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis.
1/2016	Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA.
3/2015	Interleukin 23 levels are increased in carotid atherosclerosis: possible role for the interleukin 23/interleukin 17 axis.

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Sverre Holm Research Topics

Disease

26	Atherosclerosis 10/2021 - 08/2010
16	Carotid Artery Diseases 12/2020 - 08/2010
13	Inflammation (Inflammations) 10/2021 - 01/2010
12	Atherosclerotic Plaque (Atheroma) 10/2021 - 01/2014
4	Cardiovascular Diseases (Cardiovascular Disease) 12/2020 - 01/2014
4	Ischemic Stroke 12/2018 - 01/2011
4	Carotid Stenosis (Carotid Artery Stenosis) 07/2017 - 03/2015
3	Hypoxia (Hypoxemia) 01/2016 - 10/2011
2	Thrombosis (Thrombus) 10/2021 - 07/2017
2	Acute Coronary Syndrome 10/2020 - 11/2015
2	ST Elevation Myocardial Infarction 01/2020 - 01/2013
2	Hepatocellular Carcinoma (Hepatoma) 01/2020 - 07/2015
2	Coronary Artery Disease (Coronary Atherosclerosis) 10/2019 - 01/2013
1	Thrombocytopenia (Thrombopenia) 10/2021
1	Virus Diseases (Viral Diseases) 10/2021
1	Aortic Valve Stenosis (Aortic Stenosis) 10/2020
1	Necrosis 10/2020
1	Stable Angina 10/2020
1	Fatty Liver 01/2020
1	Type 2 Diabetes Mellitus (MODY) 01/2020
1	Neoplasms (Cancer) 01/2020
1	Rheumatic Diseases (Rheumatism) 10/2019
1	Transient Ischemic Attack 12/2018
1	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 10/2018
1	Pathologic Constriction (Stenosis) 01/2017
1	Myocardial Infarction 01/2016
1	Infections 01/2016
1	Non-alcoholic Fatty Liver Disease 07/2015
1	Disease Progression 03/2015

Drug/Important Bio-Agent (IBA)

12	Messenger RNA (mRNA)IBA 01/2021 - 08/2010
7	CytokinesIBA 10/2021 - 01/2014
7	EnzymesIBA 12/2020 - 08/2010
6	Apolipoproteins E (ApoE)IBA 10/2021 - 01/2013
6	LipidsIBA 01/2021 - 01/2014
5	CholesterolIBA 10/2020 - 01/2010
5	InterleukinsIBA 10/2020 - 01/2013
5	Proteins (Proteins, Gene)FDA Link 10/2020 - 08/2010
4	RNA (Ribonucleic Acid)IBA 01/2021 - 11/2015
3	DNA Glycosylases (DNA Glycosylase)IBA 10/2021 - 01/2016
3	ChemokinesIBA 01/2021 - 09/2012
3	lipoprotein-associated coagulation inhibitor (TFPI)IBA 07/2017 - 01/2016
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2015 - 10/2011
2	LigandsIBA 01/2021 - 04/2014
2	Adenosine (Adenocard)FDA LinkGeneric 01/2021 - 01/2020
2	Deoxyribonuclease (Pyrimidine Dimer)IBA 01/2021 - 01/2020
2	Inosine FDA Link 01/2021 - 01/2020
2	InflammasomesIBA 10/2020 - 01/2017
2	Biomarkers (Surrogate Marker)IBA 10/2020 - 01/2017
2	asparaginylendopeptidase (legumain)IBA 01/2020 - 01/2017
2	Cysteine Proteases (Cysteine Protease)IBA 01/2020 - 01/2017
2	ImmunosorbentsIBA 01/2017 - 07/2015
2	Thrombin FDA Link 01/2016 - 05/2012
2	InterferonsIBA 01/2016 - 05/2012
2	Interleukin-17 (Interleukin 17)IBA 03/2015 - 01/2013
2	Chemokine CXCL13IBA 06/2014 - 09/2012
2	oxidized low density lipoproteinIBA 01/2014 - 10/2011
2	Toll-Like Receptors (Toll-Like Receptor)IBA 05/2012 - 08/2010
1	VaccinesIBA 10/2021
1	ChAdOx1 nCoV-19IBA 10/2021
1	Antigen-Antibody Complex (Immune Complex)IBA 10/2021
1	Immunoglobulin G (IgG)IBA 10/2021
1	ApolipoproteinsIBA 01/2021
1	Carrier Proteins (Binding Protein)IBA 12/2020
1	6-methyladenineIBA 12/2020
1	N-methyladenosineIBA 12/2020
1	MethyltransferasesIBA 12/2020
1	Factor VaIBA 10/2020
1	Pyrin Domain-Containing 3 Protein NLR FamilyIBA 10/2020
1	Complement System Proteins (Complement)IBA 10/2020
1	Protein Isoforms (Isoforms)IBA 01/2020
1	Lipoprotein(a)IBA 10/2019
1	Class E Scavenger Receptors (Lectin Like Oxidized Low Density Lipoprotein Receptor 1)IBA 12/2018
1	Thymidine Monophosphate (TMP)IBA 10/2018
1	Interleukin-27 (Interleukin 27)IBA 01/2017
1	Nicotinamide PhosphoribosyltransferaseIBA 01/2017
1	NAD (NADH)IBA 01/2017
1	Interleukin-6 (Interleukin 6)IBA 01/2017
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2017
1	gamma-butyrobetaine (butyrobetaine)IBA 04/2016
1	trimethyllysineIBA 04/2016
1	trimethyloxamine (trimethylamine N-oxide)IBA 04/2016
1	Carnitine (L-Carnitine)FDA LinkGeneric 04/2016
1	Thromboplastin (Tissue Factor)IBA 01/2016
1	Oxygen (Dioxygen)IBA 01/2016
1	LectinsIBA 01/2016
1	Mannose-Binding Lectin (Mannan-Binding Lectin)IBA 01/2016
1	DNA Repair EnzymesIBA 01/2016
1	Mitochondrial DNA (mtDNA)IBA 01/2016
1	DNA (Deoxyribonucleic Acid)IBA 01/2016
1	CoagulantsIBA 01/2016
1	Lymphotoxin-alpha (Lymphotoxin)IBA 07/2015
1	Interleukin-12 (IL 12)IBA 03/2015
1	Interleukin-23 (Interleukin 23)IBA 03/2015
1	Matrix Metalloproteinase 7 (Matrilysin)IBA 01/2014
1	Caseins (Casein)FDA Link 01/2014
1	Matrix Metalloproteinases (MMPs)IBA 01/2014
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2014
1	Interleukin-9 (Interleukin 9)IBA 01/2013

Therapy/Procedure

1	Percutaneous Coronary Intervention 01/2020
1	Carotid Endarterectomy 07/2017